VERTIGO. -HLA B27- Meniere's Disease

See your primary care doctor immediately if vertigo is accompanied by any of the following signs or symptoms: Headache that is unusual or severe for you
Double vision or loss of vision
Speech impairment

Diseases and Conditions
Meniere's disease
By Mayo Clinic Staff
The primary signs and symptoms of Meniere's disease are: Recurring episodes of vertigo. Vertigo is similar to the sensation you experience if you spin around quickly several times and suddenly stop. You feel as if the room is still spinning, and you lose your balance. Episodes of vertigo occur without warning and usually last 20 minutes to two hours or more, up to 24 hours. Severe vertigo can cause nausea and vomiting. Hearing loss. Hearing loss in Meniere's disease may fluctuate, particularly early in the course of the disease. Eventually, most people experience some degree of permanent hearing loss. Ringing in the ear (tinnitus). Tinnitus is the perception of a ringing, buzzing, roaring, whistling or hissing sound in your ear. Feeling of fullness in the ear. People with Meniere's disease often feel aural fullness or increased pressure in the ear. A typical episode might start with a feeling of fullness in your ear, increasing tinnitus and decreasing hearing followed by severe vertigo, often accompanied by nausea and vomiting. Such an episode might last 20 minutes to four hours, after which signs and symptoms improve. Episodes often occur in clusters, with long periods of mild or no symptoms (remission) between. Still, the severity, frequency and duration of each of these sensory perception problems vary, especially early in the disease. For example, you could have frequent episodes with severe vertigo and only mild disturbances in other sensations. Or you may experience mild vertigo and hearing loss infrequently but have frequent tinnitus that disturbs your sleep. When to see a doctor See your doctor if you experience any signs or symptoms of Meniere's disease. Because any one of these problems may be the result of other illnesses, it's important to get an accurate diagnosis as soon as possible. Vertigo is an uncommon but possible sign of other disorders, such as stroke, brain tumor, multiple sclerosis, or diseases of your heart or blood vessels (cardiovascular disease). See your primary care doctor immediately if vertigo is accompanied by any of the following signs or symptoms: Headache that is unusual or severe for you
Double vision or loss of vision
Speech impairment
Leg or arm weakness
Loss of consciousness
Falling or difficulty walking
Numbness or tingling Chest pain

http://www.entjournal.com/article/hla-b27-associated-bilateral-m-ni-re-disease

HLA-B27-associated bilateral Ménière disease

March 1, 2010 by Shamila G. Rawal, MD, Kunal H. Thakkar, MD, Kasra Ziai, BS, Peter A. Santi, MD, and Hamid R. Djalilian, MD

Abstract
We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. For immunohistochemical analysis, mouse inner ear sections were used as the tissue substrate for reaction with serum. Both patients demonstrated an increased immunofluorescence reaction compared with a normal control. We suggest that an antibody-mediated mechanism may be responsible for HLA-B27-associated Ménière disease.